The following links may be helpful when considering the role of Sense Perception in knowledge aquisition.
The universe is queerer than we can suppose. Evolutionary Biologist, Richard Dawkins makes a case for "thinking the improbable" by looking at how the human frame of reference limits our understanding of the universe. We live, he explains, in a middle-sized world and have difficulty understanding anything very large — like solar systems — or very small, like atoms.
For more information on Richard Dawkins